Development of oral controlled-release systems has been a challenge to formulation scientists because of their inability to restrain and localize the system in the targeted area of the gastrointestinal tract. Controlled/sustained release preparations using alternating routes have also been formulated but oral route still remains preferable. Bi-layer tablets are novel drug delivery systems where combination of two or more drugs in a single unit having different release profiles which improves patient compliance, prolongs the drug(s) action, avoid saw tooth kinetics resulting in effective therapy along with better control of plasma drug levels.
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